A new method of synthesizing 7-(2-hydroxy-5-oxo-1-cyclopentenyl) heptanoic acid and related compounds.

H Naora, T Ohnuki, A Nakamura

Index: Naora, Hirokazu; Ohnuki, Takashi; Nakamura, Asao Bulletin of the Chemical Society of Japan, 1988 ,  vol. 61,  # 7  p. 2401 - 2404

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Citation Number: 4

Abstract

A useful prostanoid synthon, 7-(2-hydroxy-5-oxo-1-cyclopentenyl) heptanoic acid (3), was prepared from commercially available cyclooctanone in two steps. Nine other related cyclopentanoids which are also valuable synthons for prostaglandins were obtained from 3 in reasonable yields via several steps. The procedure is capable of generating these useful synthons on a laboratory scale.