Incorporation of a thiol function in nucleosides, nucleotides, or oligonucleotides has led to a number of analogues possessing interesting biological properties. 1 For example, 2′, 3′- dideoxy-3′-mercaptonucleoside 5′-triphosphates (T, C, A, G) irreversibly stopped DNA chain elongation by AMV and HIV reverse transcriptase, and the corresponding nucleosides display antiviral activities. 2a, b Recently, we have demonstrated that another nucleotide ...
