Technetium-99m-labeling and synthesis of thymidine analogs: Potential candidates for tumor imaging

B Teng, Y Bai, Y Chang, S Chen, Z Li

Index: Teng, Bao; Bai, Yunpeng; Chang, Yu; Chen, Shizhen; Li, Zhaolong Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3440 - 3444

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Citation Number: 10

Abstract

The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1, 1-bis (hydroxymethyl) ethyl) glycine (tricine) and ethylenediamine-N, N′-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield ...