Design, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPARγ partial agonists

RK Verma, P Ghosh, V Kumar, LK Wadhwa

Index: Verma, Raman K.; Ghosh, Prithwish; Kumar, Vijay; Wadhwa, Lalit K. Journal of Chemical Sciences, 2013 , vol. 125, # 6 p. 1555 - 1571

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Abstract

Abstract The design and synthesis of benzimidazolyl and indolyl linked α-alkoxy phenylpropanoic acid derivatives and the β-keto ester analogues in an effort to develop novel peroxisome proliferator activated receptors ligands expected to exhibit PPAR α and PPAR γ partial agonism in the management of hyperglycemia and hyperlipidemia for the treatment of type 2 diabetes is reported. Computational validation of the designed ...

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