Potent and selective 1, 2, 3-trisubstituted indole NPY Y-1 antagonists

…, J Catlow, DK Dieckman-McGinty…

Index: Hipskind, Philip A.; Lobb, Karen L.; Nixon, James A.; Britton, Thomas G.; Bruns, Robert F.; Catlow, John; Dieckman-McGinty, Donna K.; Gackenheimer, Susan L.; Gitter, Bruce D.; Lyengar, Smriti; Schober, Douglas A.; Simmons, Rosa M. A.; Swanson, Steve; Zarrinmayeh, Hamideh; Zimmerman, Dennis M.; Gehlert, Donald R. Journal of Medicinal Chemistry, 1997 , vol. 40, # 23 p. 3712 - 3714

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Citation Number: 114

Abstract

Neuropeptide Y (NPY) was originally isolated from extracts of porcine brain and is named for the presence of an N-terminal tyrosine (tyr)“Y”) and a C-terminal tyrosine amide. NPY is a 36 amino acid peptide and a member of the family of neurotransmitter peptides that also includes peptide YY (PYY) and pancreatic polypeptide (PP). 1 NPY is the most abundant peptide neurotransmitter in the brain, and its receptors are prominent in both the central ...