Abstract: The rate of reduction of oxidized glutathione (GSSG) to glutathione (GSH) by thiolate anions (RS-) follows a Brfnsted relation in pK, s of the conjugate thiols (RSH): Pnuc E 0.5. This value is similar to that for reduction of Ellman's re-agent: Pnuc N 0.4-0.5. Analysis of a number of rate and equilibrium data, taken both from this work and from the literature, indicates that rate constants, k, for a range of thiolate-disulfide interchange reactions are ...
