Preparation of benzene, furan, and thiophene analogs of duocarmycin SA employing a newly-devised phenol-forming reaction.

H Muratake, A Hayakawa, M Natsume

Index: Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1558 - 1566

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Citation Number: 17

Abstract

... i)-9d] analogs of DSA lack methoxycarbonyl group at the 2-position which contributes to the chemical stability of ... n '—> £000“ MeOOC N OOH H O 0 L-malic acid 6 'A' H Chart 1 © 2000 Pharmaceutical Society of ... After the mixture had cooled, saturated NaHCO3—H20 was Vol. ...