Abstract Alkylation of 6-methyluracil, 5-fluorouracil, uracil-5-ammonium sulfate, 5- hydroxyuracil, 5-hydroxy-6-methyluracil, 3, 6-dimethyl-5-hydroxyuracil, and 1, 3, 6-trimethyl- 5-hydroxyuracil with ethylene chlorohydrin in water-alcohol medium in the presence of KOH was investigated.