Synthesis and Anti??Candida Potential of Certain Novel 1??[(3??Substituted??3??phenyl) propyl]??1H??imidazoles

MN Aboul??Enein, AAES El??Azzouny…

Index: Aboul-Enein, Mohamed Nabil; El-Azzouny, Aida Abd El-Sattar; Attia, Mohamed Ibrahim; Saleh, Ola Ahmed; Kansoh, Amany Lotfy Archiv der Pharmazie, 2011 , vol. 344, # 12 p. 794 - 801

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Citation Number: 17

Abstract

Abstract The synthesis and anti-Candida activity of 1-[(3-aroyloxy-3-phenyl) propyl]-1H- imidazoles 5a–f and 1-[(3-alkyl/aralkyl/phenyl-3-phenyl) propan-3-ol]-1H-imidazoles 5g–j are reported. The influence of the ester formation and different substitutions on the anti- Candida activity of the alcohol 4 was investigated. Among the newly developed bioactive chemical entities, compounds 5b and 5c displayed minimum inhibitory concentrations ( ...