Synthesis of substituted aryloxy alkyl and aryloxy aryl alkyl imidazoles as antileishmanial agents

K Bhandari, N Srinivas, VK Marrapu, A Verma…

Index: Bhandari, Kalpana; Srinivas, Nagarapu; Marrapu, Vijay K.; Verma, Aditya; Srivastava, Saumya; Gupta, Suman Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 291 - 293

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Citation Number: 41

Abstract

A series of aryloxy alkyl/aryl alkyl imidazoles were synthesized and evaluated in vitro as antileishmanials against Leishmania donovani. All the 19 compounds exhibited 94–100% inhibition at 10μg/mL against promastigotes and 12 compounds exhibited high inhibition with an IC50 in the range of 0.47–4.85 μg/mL against amastigotes. Promising compounds were tested further in vivo. Among all, compounds 4 and 23 with 4-CF3 aryloxy moiety ...