Methyl chymotrypsin catalyzed hydrolyses of specific substrate esters indicate multiple proton catalysis is possible with a modified charge relay triad

JD Scholten, JL Hogg, FM Raushel

Index: Journal of the American Chemical Society, , vol. 110, # 24 p. 8246 - 8247

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Citation Number: 22

Abstract

... a-Chymotrypsin has been chemically modified by using methyl p-nitrobenzenesulfonate which has been ... L. In Enzyme Mechanisms; Page, MI, Williams, A,, Eds.; Royal Society of Chemistry: London, 1987 ... 0002-7863/88/ 15 10-8246.f.01 SO/O 0 1988 American Chemical Society ...