Reactive and Functional Polymers

A cancer-targetable copolymer containing tyrosine segments for labeling radioactive halogens

Y Qi, N Li, Q Xu, X Xia, J Ge, J Lu

Index: Qi, Yu; Li, Najun; Xu, Qingfeng; Xia, Xuewei; Ge, Jianfeng; Lu, Jianmei Reactive and Functional Polymers, 2011 , vol. 71, # 4 p. 390 - 394

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Citation Number: 10

Abstract

A series of cancer-targetable copolymers containing rhodamine and tyrosine segments were synthesized and further labeled with isotope 125I. Copolymers with different molecular weights (PRTH-1, PRTH-2 and PRTH-3) formed aggregates in water with average diameters of 66nm, 191nm and 137nm, respectively. The cancer cell targeting properties of the copolymers were investigated by comparing BEL-7402 liver cancer cells and L-02 human ...