Abstract In this work, two new effective methodologies have been adopted for the preparation of 5-(2′-bromobenzyloxy) pyrimidine-2, 4-diones 6 (a–k). In the first methodology, 5-hydroxy uracils 4 (a–f) were alkylated with 2-bromobenzyl bromide 5a or 2- bromo-5-methoxy benzyl bromide 5b under phase transfer catalysis condition using lithium hydroxide/tetrabutyl ammonium bromide in N, N-dimethylformamide at 45° C, and in the ...
