Tetrahedron Letters

A 1, 5-benzothiazepine synthesis

CBW Phippen, CSP McErlean

Index: Phippen, Christopher B.W.; McErlean, Christopher S.P. Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1490 - 1492

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Citation Number: 20

Abstract

A major challenge facing the pharmaceutical industry is the development of sustainable manufacturing processes that deliver target compounds in an energy efficient and ecologically benign manner. 15, 16 and 17 In this regard, the use of water-tolerant chemistry has become increasingly important. 18, 19 and 20 We have recently reported the energy efficient and operationally simply 'on-water' 21 addition of anilines to N-acryloyl-2,5-dimethylpyrrole. 22 During that work, ...