Experimental and theoretical insights into the mechanisms of sulfate and sulfamate ester hydrolysis and the end products of type I sulfatase inactivation by aryl …

SJ Williams, E Denehy, EH Krenske

Index: Williams,A.; Douglas,K.T. Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1974 , p. 1727 - 1732

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Citation Number: 10

Abstract

Type I sulfatases catalyze the hydrolysis of sulfate esters through S–O bond cleavage and possess a catalytically essential formylglycine (FGly) active-site residue that is post- translationally derived from either cysteine or serine. Type I sulfatases are inactivated by aryl