Synthesis and biological activity of novel 4-phenyl-1, 8-naphthyridin-2 (1H)-on-3-yl ureas: Potent acyl-CoA: cholesterol acyltransferase inhibitor with improved …

H Ban, M Muraoka, K Ioriya, N Ohashi

Index: Ban, Hitoshi; Muraoka, Masami; Ioriya, Katsuhisa; Ohashi, Naohito Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 44 - 48

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Citation Number: 9

Abstract

4-Aryl-1, 8-naphthyridin-2 (1H)-on-3-yl urea derivatives with hydrophilic groups were synthesized in order to improve aqueous solubility and pharmacokinetic property. SMP-797 possessing (4-aminophenyl) ureido and 3-(hydroxypropoxyphenyl) moieties showed potent ACAT inhibitory activity and excellent oral efficacy.

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