Chinese Chemical Letters

First total synthesis of eudistalbin A

PY Zhang, JL Wang, SB Wan, T Jiang

Index: Zhang, Pu Yong; Wang, Jun Lei; Wan, Sheng Biao; Jiang, Tao Chinese Chemical Letters, 2010 , vol. 21, # 8 p. 889 - 891

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Citation Number: 4

Abstract

Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity (ED50< 3.2 μg/mL) in vitro against the growth of KB human buccal carinoma cells. The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC50 value of 2.1 μmol/L using the metabolic assay MTT. All structures of new compounds were confirmed by 1H NMR, 13C NMR, HRMS and optical ...