e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Mapping the catechol binding site in dopamine D1 receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues
LA Bonner, U Laban, BR Chemel, JI Juncosa…
Index: Bonner, Lisa A.; Laban, Uros; Chemel, Benjamin R.; Juncosa, Jose I.; Lill, Markus A.; Watts, Val J.; Nichols, David E. ChemMedChem, 2011 , vol. 6, # 6 p. 1024 - 1040
Abstract A novel class of isochroman dopamine analogues, originally reported by Abbott Laboratories, have> 100-fold selectivity for D 1-like over D 2-like receptors. We synthesized a parallel series of chroman compounds and showed that repositioning the oxygen atom in the heterocyclic ring decreases potency and confers D 2-like receptor selectivity to these compounds. In silico modeling supports the hypothesis that the altered pharmacology for ...
