Synthesis of neoflavones by Suzuki arylation of 4-substituted coumarins

GM Boland, DMX Donnelly, JP Finet…

Index: Boland, Gerard M.; Donnelly, Dervilla M. X.; Finet, Jean-Pierre; Rea, Martin D. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 21 p. 2591 - 2597

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Citation Number: 74

Abstract

Palladium-catalysed coupling of the 4-chloro-or 4-bromo-coumarins 1–4 with arylboronic acids 5–13 under the Suzuki reaction conditions constitutes an efficient access to 4- arylcoumarins. These 4-arylcoumarins can also be obtained in good yields (70–97%) by treatment of 4-trifluoromethyl-sulfonyloxycoumarins 35–38 with arylboronic acids under modified Suzuki reaction conditions, involving the use of copper (I) iodide as a co-catalyst.