A concise synthetic strategy toward cyclic α, α-disubstituted α-amino acids, 1-substituted 4- aminopiperidine-4-carboxylic acids have been developed. The synthetic route is a reductive amination of dimethyl bis (dioxolanemethyl) malonate with various amines, followed by Curtius rearrangement. This synthetic route is capable of synthesizing 4-aminopiperidine-4- carboxylic acids bearing a bulky substituent and optically active ones bearing a pendent ...
