Synthesis and Monoamine Oxidase Inhibitory Activity of 3??Substituted 5H??Indeno [1, 2??c] pyridazines

…, B Testa, V Carta, C Altomare, A Carotti

Index: Kneubuhler; Carta; Altomare; Carotti; Testa Helvetica Chimica Acta, 1993 , vol. 76, # 5 p. 1956 - 1963

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Citation Number: 27

Abstract

Abstract The one-pot synthesis of nine 5H-indeno [1, 2-c] pyridazines is described. These compounds are shown to be potent, reversible inhibitors of monoamine oxidase B (MAO-B) with little or no effect on monoamine oxidase A (MAO-A). Qualitative structure-activity relations indicate that the MAO-B inhibitory activity is strongly influenced by electronic and bulk properties of substitutents.