Design, synthesis, antimicrobial, anticancer evaluation, and QSAR studies of 4-(substituted benzylidene-amino)-1, 5-dimethyl-2-phenyl-1, 2-dihydropyrazol-3-ones

S Sigroha, B Narasimhan, P Kumar, A Khatkar…

Index: Sigroha, Sumit; Narasimhan, Balasubramanian; Kumar, Pradeep; Khatkar, Anurag; Ramasamy, Kalavathy; Mani, Vasudevan; Mishra, Rakesh Kumar; Majeed, Abu Bakar Abdul Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3863 - 3875

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Citation Number: 21

Abstract

Abstract A series of 4-(substituted benzylidene-amino)-1, 5-dimethyl-2-phenyl-1, 2- dihydropyrazol-3-ones (1–17) was synthesized and tested in vitro for its antimicrobial and anticancer potentials. The biological screening results indicated that compounds having m- chloro substituent on benzaldehyde portion showed antimicrobial potential, whereas compounds having chloro, methoxy, and hydroxyl groups showed anticancer potential. ...