Tetrahedron: Asymmetry

Lipase-catalyzed kinetic resolution of 3-butyn-2-ol

K Nakamura, K Takenaka, A Ohno

Index: Nakamura, Kaoru; Takenaka, Keishi; Ohno, Atsuyoshi Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4429 - 4439

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Citation Number: 28

Abstract

Twenty-three lipases were subjected to an evaluation of selectivities in transesterification of 2 with vinyl acetate in hexane (Eq. 1). Results are summarized in Table 1. Most lipases (including a further 13 lipases which are not listed in Table 1) react selectively with the (R)-enantiomer while three lipases (LIP, LPL and OF) prefer to react with the (S)-enantiomer. Three lipases (Amano AK, AH and PS) were selected and employed for further studies, because they ...