Styrylheterocycles as a novel class inhibitor of cyclooxygenase-2-mediated prostaglandin E 2 production

SK Lee, EJ Park, E Lee, HY Min, EY Kim, T Lee…

Index: Lee, Sang Kook; Park, Eun-Jung; Lee, Eunjung; Min, Hye-Young; Kim, Eun-Young; Lee, Taeho; Kim, Sanghee Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2105 - 2108

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Citation Number: 12

Abstract

The inhibitory effects of a series of styrylheterocycles on the production of cyclooxygenase-2- mediated prostaglandin E2 (PGE2) were evaluated in lipopolysaccharide-stimulated RAW264. 7 murine macrophages. A new series of potential inhibitors, including 3-[2-(4- methoxy-phenyl)-vinyl]-thiophene, have been identified, thus providing novel chemical leads for the further development of potential inhibitors in this capacity. The suppression of COX- ...