New cyclobutyl analogs of nucleosides. Part 2. Synthesis and antiviral evaluation of 2-amino-7-[3, 3-bis (hydroxymethyl) cyclobut-1-yl]-3H, 7H-pyrrolo-[2, 3-d] pyrimidin …

…, M Legraverend, A Zerial, M Lemaitre, C Huel…

Index: Boumchita, H; Legraverend, M; Zerial, A; Lemaitre, M; Huel, C; Bisagni, E European Journal of Medicinal Chemistry, 1991 , vol. 26, # 6 p. 613 - 617

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Citation Number: 5

Abstract

Abstract The synthesis and antiviral evaluation of a series of 3, 3-dihydroxymethyl cyclobutane nucleoside analogs related to the natural anti-HIV nucleoside, oxetanocin A are reported. The different purine and pyrimidine nucleoside analogs described in this paper have been obtained from 1-amino-3, 3-dibenzyloxymethylcyclobutane. The compounds were tested against HSV-1, HCMV and HIV-1 in cell cultures, but none of them exhibited ...