Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogs derived from common chiral pools:(+)-( …

…, I Tomoskozi, L Gruber, E Baitz-Gacs…

Index: Beres; Sagi; Tomoskozi; Gruber; Baitz-Gacs; Otvos; De Clercq Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1353 - 1360

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Citation Number: 35

Abstract

Enantiomerically pure (+)-and (-)-carbocyclic thymidine,(-)-carbocyclic 3'-epi-thymidine,(+)- carbocyclic 3'-deoxy-3'-azidothymidine,(+)-carbocyclic 2, 3'-0-anhydrothymidine,(+)- carbocyclic 3'-0, 6'-methylenethymidine, and (+)-(6's)-carbocyclic 6'-methylthymidine were synthesized in a stereospecific manner from common chiral pools of (+)-(1R, 5S)-and (-)-(1S, 5R)-2-oxabicyclo [3.3. 0] oct-6-en-3-one and evaluated for antiviral activity.(+)- ...