Synthesis and antiinflammatory activity of some new 1, 3, 5-trisubstituted pyrazolines bearing benzene sulfonamide

IG Rathish, K Javed, S Ahmad, S Bano, MS Alam…

Index: Rathish; Javed, Kalim; Ahmad, Shamim; Bano, Sameena; Alam; Pillai; Singh, Surender; Bagchi, Vivek Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 255 - 258

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Citation Number: 115

Abstract

Nineteen new 2-pyrazoline bearing benzenesulfonamide derivatives were synthesized by condensing chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride. Their chemical structures were proved by means of IR, 1H NMR, 13C NMR, mass spectroscopic and elemental analyses data. These compounds were tested at dose of 20mg/kg for their anti-inflammatory activity in carrageenan-induced rat paw edema model and volume of ...