An investigation was conducted to determine whether the cross-metathesis (CM) of allyl halides tolerates amide groups. The results show that the ruthenium-based complexes I–III serve as poor catalysts for the CM of allyl halides with olefins that contain an N, N- dimethylamide group. In contrast, the Grubbs–Hoveyda–Blechert second generation catalyst (III) efficiently promotes these processes with olefins bearing a Weinreb amide group. ...
[Satcharoen, Vachiraporn; McLean, Neville J.; Kemp, Stephen C.; Camp, Nicholas P.; Brown, Richard C. D. Organic Letters, 2007 , vol. 9, # 10 p. 1867 - 1869]
