Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo [1, 2-a] pyridine against human cytomegalovirus (HCMV) and varicella-zoster …

…, C Enguehard-Gueiffier, R Snoeck, G Andrei…

Index: Veron, Jean-Baptiste; Enguehard-Gueiffier, Cecile; Snoeck, Robert; Andrei, Graciela; De Clercq, Erik; Gueiffier, Alain Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 22 p. 7209 - 7219

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Citation Number: 17

Abstract

The synthesis of original imidazo [1, 2-a] pyridines bearing a phenethylthiomethyl side chain at the 3 position and a (hetero) aryl substituent on the 6 or 8 position, and their antiviral activities are reported. From the synthesized compounds, the 6-halogeno and 6- phenylimidazo [1, 2-a] pyridine derivatives 4c–d and 5b were the most potent against human cytomegalovirus (CMV) and/or varicella-zoster virus (VZV), whereas several other ...