Tetrahedron letters

Solid-phase synthesis of 2-cyanoquinazolin-4 (3H)-one and 2, 3-dihydrooxazolo [2, 3-b] quinazolin-5-one derivatives utilizing resin-bound anthranilic acid derivatives

MK Jeon, DS Kim, HJ La, DC Ha, YD Gong

Index: Jeon, Moon-Kook; Kim, Dong-Su; Hyun, Ju La; Ha, Deok-Chan; Gong, Young-Dae Tetrahedron Letters, 2005 , vol. 46, # 44 p. 7477 - 7481

Full Text: HTML

Citation Number: 15

Abstract

We were able to obtain 2-cyanoquinazolin-4 (3H)-ones in 35–60% four-step overall isolated yields and 2, 3-dihydrooxazolo [2, 3-b] quinazolin-5-ones in 20–71% four-step overall isolated yields utilizing polymer-bound anthranilic acid derivatives, and 6-amino-2- cyanoquinazolin-4 (3H)-ones in 30–44% six-step overall isolated yields making use of anthranilic acid derivative resin via dithiazole resins and. The reactions on solid phase ...