Tetrahedron

Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions

M Bouktaib, S Lebrun, A Atmani, C Rolando

Index: Bouktaib, Mohamed; Lebrun, Stephane; Atmani, Aziz; Rolando, Christian Tetrahedron, 2002 , vol. 58, # 50 p. 10001 - 10009

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Citation Number: 84

Abstract

A new methodology for the hemisynthesis of all the five O-monomethylated analogues of quercetin (3′-O-methylquercetin (isorhamnetin), 4′-O-methylquercetin (tamarixetin), 3-O- methylquercetin, 5-O-methylquercetin (azaleatin) and 7-O-methylquercetin (rhamnetin)) through sequential protection of the different phenolic functions of quercetin is reported.