Palladium??Catalysed Amination of Aryl??and Heteroaryl Halides Using tert??Butyl Tetraisopropylphosphorodiamidite as an Easily Accessible and Air??Stable Ligand

GD Roiban, G Mehler, MT Reetz

Index: Roiban, Gheorghe-Doru; Mehler, Gerlinde; Reetz, Manfred T. European Journal of Organic Chemistry, 2014 , vol. 2014, # 10 p. 2070 - 2076

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Citation Number: 8

Abstract

Abstract The phosphorus compound tert-butyl tetraisopropylphosphorodiamidite, prepared from bis (diisopropylamino) chlorophosphine, is an excellent ligand for palladium-catalysed Buchwald–Hartwig amination of aryl-and heteroaryl chlorides and bromides. Based on its ready accessibility and air-stability, this amination protocol is a practical approach to the synthesis of industrially important aryl-and heteroarylamines.