Modified (NHC) Pd (allyl) Cl (NHC= N-heterocyclic carbene) complexes for room-temperature Suzuki-Miyaura and Buchwald-Hartwig reactions

N Marion, O Navarro, J Mei, ED Stevens…

Index: Marion, Nicolas; Navarro, Oscar; Mei, Jianguo; Stevens, Edwin D.; Scott, Natalie M.; Nolan, Steven P. Journal of the American Chemical Society, 2006 , vol. 128, # 12 p. 4101 - 4111

Full Text: HTML

Citation Number: 610

Abstract

A series of (NHC) Pd (R-allyl) Cl complexes [NHC: IPr= N, N'-bis (2, 6-diisopropylphenyl) imidazol-2-ylidene, SIPr= N, N'-bis (2, 6-diisopropylphenyl)-4, 5-dihydroimidazol-2-ylidene; R= H, Me, gem-Me2, Ph] have been synthesized and fully characterized. When compared to (NHC) Pd (allyl) Cl, substitution at the terminal position of the allyl scaffold favors a more facile activation step. This translates into higher catalytic activity in the Suzuki-Miyaura and ...