A CONVENIENT SYNTHESIS OF METHYL 4-AMINO-5-CHLORO-2-MTHOXYBENZOATE

RL Ehrenkaufer, JG Scripko…

Index: Ehrenkaufer, Richard L.; Scripko, James G.; Hoffman, Patricia L. Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 64 - 66

Full Text: HTML

Citation Number: 3

Abstract

A common feature of many neuroleptic drugs available on the market today is the 4-amino-5- chloro-2-methoxybenzoic acid moiety.* V2 During a program of synthesizing a number of these drugs and their radiolabelled analogues for evaluation as potential Positron Emission Tomography imaging agents, we needed to develop a convenient synthesis of the parent acid. Published syntheses involved protectiondeprotection of the nitrogen? to prevent ...