Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator

X Deng, X Zhao, J Han, J Wang…

Index: Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493

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Abstract

... In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy. ... Letters in Drug Design & Discovery, 2012, Vol. 9, No. 5 493 ...