View all references ] a one-pot condensation of aldehyde, acetoacetate, and urea under strongly acidic conditions, is one of the most useful multicomponent reactions (MCRs), gaining increasing importance in organic and medicinal chemistry because of its the capacity to generate multifunctionalized products including 3,4-dihydropyrimidin-2-ones, their thiones analogs, and other related heterocyclic compounds. Therefore, many improvements and modifications of the Biginelli reaction ...
