Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl) benzyl]-4, 5-dimethylpyridazin-3 (2H)-ones as potent poly (ADP–ribose) polymerase-1 (PARP-1) …

F Ferrigno, D Branca, O Kinzel, S Lillini, LL Bufi…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 3 p. 1100 - 1105

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Citation Number: 13

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... In this Letter we describe the identification and optimization of a new series of dimethylpyridazin-3(2H)-one PARP inhibitors B leading to very potent analogs with clean off-target profiles and improved pharmacokinetic properties both ...