Fibrin-stabilizing factor inhibitors. 12. 5-Dibenzylaminopentylamine and related compounds, a new type of FSF [fibrin-stabilizing factor] inhibitors

KJ Hoffmann, P Stenberg, C Ljunggren…

Index: Hoffmann; Stenberg; Ljunggren; Svensson; Nilsson Journal of Medicinal Chemistry, 1975 , vol. 18, # 3 p. 278 - 284

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Citation Number: 14

Abstract

Method A. The appropriate secondary amine was alkylated using w-chloroalkylnitriles, usually 5-chlorovaleronitrile. The nitriles thus formed (compounds 14-26, 29, 33, 34, 36, 37, and 40, Table I) were then reduced to the corresponding primary amine using LiAlH4. This yielded the inhibitors 47, 48, 52-56, 61, 62, 64, 71, 73-75 and 77-80.