Abstract: 4-Biphenylacetic acid (4-BPA), the active metabolite of NSAID fenbufen has been modified using mutual prodrug approach. Number of 4-BPA derivatives have been synthesised as potential mutual prodrugs by the attachment of several phytophenols/alcohol as promoieties through ester linkage, directly as well as through spacers, with the objective of obtaining safer NSAIDs devoid of their ulcerogenic side effects. The structures of these ...
