Journal of the American Chemical Society

16-Substituted Steroids. VIII. 1, 3, 5 (10)-Estratrien-3-ol-16-one

MN Huffman, MH Lott

Index: Huffman; Lott Journal of the American Chemical Society, 1953 , vol. 75, p. 4327,4328

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Citation Number: 6

Abstract

Mild Clemmensen Reduction of 1, 3, 5 (lO)-Estratrien3, 17&diol-16-one.-In 45 ml. of 95% ethanol containing 3 ml. of 6-V hydrochloric acid was dissolved 603 mg. of 1, 3, 5-(lO)- estratrien-3, 17P-diol-16-onea (mp. 232-234.5')(I). To this solution was added 15 g. of amalgamated zinc (20-mesh), and the resulting mixture refluxed on the steam-bath for five hours, with the addition of 3". portions of 6 N hydrochloric acid at 15-minute intervals. At ...