N-Acylated and N, N′-diacylated imidazolidine-2-thione derivatives and N, N′-diacylated tetrahydropyrimidine-2 (1H)-thione analogues: Synthesis and …

…, A Ranise, S Schenone, C Rosano, P La Colla…

Index: Cesarini, Sara; Spallarossa, Andrea; Ranise, Angelo; Schenone, Silvia; Rosano, Camillo; La Colla, Paolo; Sanna, Giuseppina; Busonera, Bernardetta; Loddo, Roberta European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1106 - 1118

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Citation Number: 20

Abstract

Fifty-one acylthioureas (ATUs) incorporating imidazolidine-2-thione or its upper cyclohomologue were prepared by parallel synthesis and evaluated against a high number of human cancer cell lines for antiproliferative activity. ATUs 1o (3, 5-dichlorobenzoyl), 1s (2- furoyl), 3s (2-furoyl) and 1t (2-thenoyl) displayed activity against leukemia, melanoma LOX IMVI, non-small cell lung NCI-H522, renal 786-0, CAKI-1, SN12C, UO-31 and breast ...