Synthetic Communications

Selective Ring Omethylation of Hydroxybenzaldehydes Via Their Mannich Bases

AK Sinhababu, RT Borchardt

Index: Sinhababu, Achintya K.; Borchardt, Ronald T. Synthetic Communications, 1982 , vol. 12, # 12 p. 983 - 988

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Citation Number: 15

Abstract

Abstract In connection with our synthesis of analogs of serotonin neuro-toxins1 we needed access to 4-hydroxy-3-methoxy-5-methylbenzaldehyde (1) in quantities. The only previous method for the synthesis of 1 involved conversion of o-vanillin to 2-hydroxy-3-