Dual stimuli-responsive poly (N-isopropylacrylamide)-b-poly (L-histidine) chimeric materials for the controlled delivery of doxorubicin into liver carcinoma

RP Johnson, YI Jeong, JV John, CW Chung…

Index: Johnson, Renjith P.; Jeong, Young-Il; John, Johnson V.; Chung, Chung-Wook; Kang, Dae Hwan; Selvaraj, Manickam; Suh, Hongsuk; Kim, Il Biomacromolecules, 2013 , vol. 14, # 5 p. 1434 - 1443

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Citation Number: 55

Abstract

A series of dual stimuli responsive synthetic polymer bioconjugate chimeric materials, poly (N-isopropylacrylamide) 55-block-poly (l-histidine) n [p (NIPAM) 55-bp (His) n](n= 50, 75, 100, 125), have been synthesized by employing reversible addition–fragmentation chain transfer polymerization of NIPAM, followed by ring–opening polymerization of α-amino acid N-carboxyanhydrides. The dual stimuli responsive properties of the resulting ...