Cholecystokinin heptapeptide analogues with multiple modification in peptide chain

…, J Pospíšek, L Maletínská, J Slaninová

Index: Hlavacek, Jan; Pirkova, jana; Zertova, Miroslava; Pospisek, Jan; Maletinska, Lenka; Slaninova, Jirina Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 11 p. 2761 - 2765

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Citation Number: 4

Abstract

Abstract Using solid phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr (SO 3-Na+)-Met-Gly-Trp-Met-Asp-Phe-NH 2) Ia and its seven analogues Ib-Ih. In the analogues Ib and Ic the Met residue in the carboxyterminal part of the molecule was substituted for L-or D-Phe Me 3. In the analogues Id and Ie with Phe residue substituted by L- or D-Phe Me 3 the Neo was inserted in the place of this Met residue and in the analogues ...