The Journal of Organic Chemistry

Oxidative decarboxylation and decarbonylation of 3, 3-dialkyl-2-oxo carboxylic acids and esters

N Rabjohn, RM Schwarz

Index: Rabjohn, Norman; Schwarz, R. M. Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1931 - 1932

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Citation Number: 2

Abstract

Trialkylacetic acid derivatives have been reported to have muscle-relaxing properties,'and many procedures are available for the preparation of the related acids. 2 Alkylation of a- metalated a-branched acids affords good yields (65-75%) of the trisubstituted acids, however, steric factors may limit the size of the three alkyl groups. The availability of 2-oxo acids and esters [R1&R3CCOCO2H-(R)] in which R1, Rz, and R3 are unlike and may ...