Synthesis and biological activity of 1, 2, 4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors

LJ Street, R Baker, T Book, CO Kneen…

Index: Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2690 - 2697

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Citation Number: 124

Abstract

... There has been a surge of pharmaceutical interest re- cently1p2 in agents capable of stimulating central cholinergic transmission following report ~ ~ v ~ . ~ ~ ~ which consistently in- dicate major deficits in cerebral cholinergic ... Journal of Medicinal Chemistry, 1990, Vol. ...