Properties of Oligonucleotide with Phenyl-Substituted Carbocyclic Nucleoside Analogs for the Formation of Duplex and Triplex DNA

T Nasr, Y Taniguchi, T Takaki, H Okamura…

Index: Nasr, Tamer; Taniguchi, Yosuke; Takaki, Tomoko; Okamura, Hidenori; Sasaki, Shigeki Nucleosides, Nucleotides and Nucleic Acids, 2012 , vol. 31, # 12 p. 841 - 860

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Abstract

(1 S, 3 S, 4 R)-1-Phenyl-1-thymidyl-3-hydroxy-4-hydroxymethylcyclopentane (10) and their analogs were synthesized, incorporated into the oligodeoxynucleotides, and their properties were evaluated for the formation of duplex and triplex DNA. The known chiral cyclopentanone derivative was converted into the corresponding ketimine sulfonamide derivative, which was subjected to a stereoselective PhLi addition. The formed ...