The development of potential new fluorine-18 labelled radiotracers for imaging the GABA A receptor

…, CL Jones, DR Bouvet, PA Jones, DM O'Shea…

Index: Jackson, Alexander; Guilbert, Benedicte B.; Plant, Stuart D.; Goggi, Julian; Battle, Mark R.; Woodcraft, John L.; Gaeta, Alessandra; Jones, Clare L.; Bouvet, Denis R.; Jones, Paul A.; O'Shea, Dennis M.; Zheng, Penny Hao; Brown, Samantha L.; Ewan, Amanda L.; Trigg, William Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 821 - 826

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Citation Number: 10

Abstract

Positron emission tomography (PET) using the tracer [11C] Flumazenil has shown changes in the distribution and expression of the GABAA receptor in a range of neurological conditions and injury states. We aim to develop a fluorine-18 labelled PET agent with comparable properties to [11C] Flumazenil. In this study we make a direct comparison between the currently known fluorine-18 labelled GABAA radiotracers and novel ...