Tetrahedron

Palladium-catalyzed synthesis of quinoxaline derivatives

JM Wallace, BCG Söderberg, J Tamariz, NG Akhmedov…

Index: Wallace, Jeffery M.; Soederberg, Bjoern C.G.; Tamariz, Joaquin; Akhmedov, Novruz G.; Hurley, Mathew T. Tetrahedron, 2008 , vol. 64, # 41 p. 9675 - 9684

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Citation Number: 15

Abstract

A palladium-catalyzed reductive N-heteroannulation of enamines derived from 2- nitrobenzenamines forming mixtures of 1, 2-dihydroquinoxalines and 3, 4-dihydroquinoxalin- 2-ones is described. The reactions are performed using bis (dibenzylideneacetone) palladium (0), 1, 3-bis (diphenylphosphino) propane, and 1, 10-phenanthroline in DMF under 6atm of carbon monoxide at 70° C.