Synthesis of 1, 3-disubstituted symmetrical/unsymmetrical ureas via Cs2CO3-catalyzed transamination of ethylene carbonate and primary amines

…, YP Patil, AG Panda, BM Bhanage

Index: Jagtap, Sachin R.; Patil, Yogesh P.; Panda, Anil G.; Bhanage, Bhalchandra M. Synthetic Communications, 2009 , vol. 39, # 12 p. 2093 - 2100

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Citation Number: 11

Abstract

Abstract Cs2CO3-catalyzed transamination of primary amines and ethylene carbonate proceeds to form 1, 3-disubstituted symmetrical/unsymmetrical ureas in excellent yields. The effect of different reaction parameters such as influences of bases, temperature, and reaction time were investigated for the title reaction.

~25%

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~92%

~11%

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~17%

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~34%

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~72%

~36%

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~45%

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~9%

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~10%

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~15%

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~19%

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~11%

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~91%

~84%

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